Type 1 Diabetes

How AAGP® could help break through current treatment barriers

In the U.S., more than 34 million adults — about 10% — have diabetes, which is a chronic condition that causes high blood sugar.
In Type 2 diabetes, the body doesn’t properly use insulin, causing dangerous swings in blood sugar levels. But in Type 1 diabetes, also known as juvenile diabetes, the body doesn’t make insulin at all. The resulting uncontrolled blood sugar levels can cause life-threatening complications, and people with this disease must take insulin every day in order to survive. More than a million people have Type 1 diabetes, including almost 200,000 children and teens.
Type 1 diabetes is an incurable disease. Untreated, it can be fatal. But with AAGP®, there is hope for a treatment that brings freedom.


The causes of Type 1 diabetes

Diet and lifestyle don’t cause Type 1 diabetes. Rather, this disease is thought to be cause by an autoimmune response in which the body attacks its own pancreas cells, destroying its ability to produce insulin. This autoimmune response, like many other autoimmune diseases, could be triggered by environmental factors, genetics, or even a viral infection.

The symptoms of Type 1 diabetes

In Type 1 diabetes, symptoms can develop rapidly, and they may even be quite severe. Although frequently diagnosed in young people, Type 1 diabetes can develop at any age. Symptoms of Type 1 diabetes include:

  • Frequent urination
  • Extreme hunger or thirst
  • Fatigue
  • Slow-healing wounds
  • Blurry vision
  • Weight loss
  • Numbness or tingling in hands or feet
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Treatments for Type 1 diabetes

Presently, there is one treatment for Type 1 diabetes: Insulin. The diabetic must frequently test their blood sugar so that they administer the right dosage of insulin to keep their blood sugar levels in check. Insulin is typically delivered via a self-administered injection multiple times per day. There are also insulin pumps, which are devices that can be programmed to deliver specific amounts or a steady dose.

AAGP® as a potential solution

But there may be another solution. There exists in the pancreas a type of cell called an islet cell. These cells produce the insulin that is so vital to regulating blood sugar levels. At ProtoKinetix, we are actively pursuing Phase 1 research in islet cells treated with AAGP®PXX-001, our proprietary molecule that may extend the life of these cells. Our hope is that AAGP®-treated islet cells can be used in cell transplants, giving a patient’s pancreas an entirely new ability to produce insulin on its own. Called the Edmonton Protocol, these transplants are already a well-documented treatment for Type 1 diabetes. Islet cells treated with AAGP® have the potential to change lives by improving outcomes for these transplants.

ProtoKinetix research and clinical trials

Find out what we’ve learned so far about the impact AAGP® could have in the field of diabetes research and treatment.

Market potential for Type 1 diabetes

The market for Type 1 diabetes is expected to see a compound annual growth rate of 7.9%¹ by 2025, to reach $9.6 billion worldwide. Rising prevalence of this chronic disease combined with the need for lifelong medication is a unique selling point for this market; market drivers also include growing global access to medication, improved diagnostic procedures, and rising healthcare spending worldwide. As a company we hope to contribute to ending this disease through the curative potential of regenerative medicine. The market potential for effective treatments is huge.

¹Market Research Future

2019 Market Revenuet:

2025 Market Forecast:

$9.6 Billion


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